Gemins 2–8 and Unr‐interacting protein (UNRIP) are intimate partners of the survival motor neuron (SMN) protein, which is the determining factor for the neuromuscular disorder spinal muscular atrophy (SMA). The most documented role of SMN, Gemins and UNRIP occurs within the large macromolecular SMN complex and involves the cytoplasmic assembly of spliceosomal uridine‐rich small nuclear ribonucleoproteins (UsnRNPs), a housekeeping process critical in all cells. Several reports detailing alternative functions for SMN in either motor neurons or skeletal muscles may, however, hold (...) the answer to the extreme neuromuscular tissue specificity observed in SMA. Recent discoveries indicate that collaboration between SMN and Gemins also extends to these non‐canonical functions, hence raising the possibility that mutations in Gemin genes may be the cause of unlinked neuromuscular hereditary syndromes. This review evaluates the functions of Gemins and UNRIP inside the SMN complex and discusses whether these less notorious SMN complex members are capable of acting independently of SMN. (shrink)

Drawing on ethical and legal frameworks in the Netherlands, the United States and France, we examine whether physicians are expected to inform patients about potentially relevant opportunities for expanded access to investigational drugs. While we found no definitive legal obligation, we argue that physicians have a moral obligation to discuss opportunities for expanded access with patients who have run out of treatment options to prevent inequality, to promote autonomy, and to achieve beneficence.

Insight experiences are sudden, persuasive, and can accompany valuable new ideas in science and art. In this preregistered experiment, we aim to validate a novel visceral and continuous measure of insight problem solving and to test whether real-time and embodied feelings of insight can predict correct solutions. We report several findings. Consistent with recent work, we find a strong positive relationship between Aha moments and accuracy for problems that demand implicit processing. We also found that the intensity of the insight (...) experience further predicted the accuracy of solutions and participants naturally embodied the intensity of their insight experiences by squeezing the dynamometer more tightly. Intriguingly, this unintentional embodiment further predicted the accuracy of solutions. We suggest that the dynamometer complements previous measures by (1) simultaneously capturing both process and feeling in real-time, (2) highlights the value of measuring Aha moments on a continuum of intensity, and (3) firmly establishes that the impulsive feeling of Aha can carry information about the veracity of an idea. We discuss the findings in light of a recent theoretical account of how feelings of insight may act as a heuristic to select ideas from the stream of consciousness. (shrink)

This work documents the ethical dilemmas faced by anthropologists and researchers in general when investigating Amerindian communities.

False “Aha!” moments can be elicited experimentally using the False Insight Anagram Task (FIAT), which combines semantic priming and visual similarity manipulations to lead participants into having “Aha!” moments for incorrect anagram solutions. In a preregistered experiment (N = 255), we tested whether warning participants and explaining to them exactly how they were being deceived, would reduce their susceptibility to false insights. We found that simple warnings did not reduce the incidence of false insights. On the other hand, participants who (...) were given a detailed explanation of the methods used to deceive them experienced a small reduction in false insights compared to participants given no warning at all. Our findings suggest that the FIAT elicits a robust false insight effect that is hard to overcome, demonstrating the persuasive nature of false insights when the conditions are ripe for them. (shrink)

Nowadays, around half of the global population lives in urban areas. This rate is expected to increase up to two-thirds by the year 2050. Most studies analyze urban dynamics in wide geographic ranges, focusing mainly on cities. According to them, the global population is spatially distributed in two extremes: large urban agglomerations and rural deserts. However, this remark is excessively general and imprecise. For this reason, it remains essential to analyze these dynamics at other spatial scales. A close-up look in (...) thinly populated regions shows how urban dynamics are also noticeable. In this paper, we analyze spatiotemporal patterns of population distribution in a predominantly rural area by applying a local-scale approach. These patterns are represented by using spatial networks with nodes representing the human settlements and links showing hierarchies between nodes. This case study is conducted in a small municipality located in northwestern Spain. It is a predominantly rural area with a very particular spatial pattern of population distribution. (shrink)

The authors of this volume discuss the relevance and influence of various Old and New Testament documents, and early Christian and Jewish texts in terms of their impact in shaping the moral character, identity, and behaviour of the specific communities in which they were produced as well as their ethical application throughout the centuries. Against a narrow understanding of ethics, the term "application" is not used to analyse the texts of the Bible as step-by-step manuals for moral conduct. Rather, the (...) contributors engage with biblical texts within the framework of a complex hermeneutical process of application of the relevance of these texts in contemporary ethical discourse. Contributors: Paul N. Anderson, Robert L. Brawley, Cilliers Breytenbach, Ulrich Busse, R. Alan Culpepper, Jan Willem van Henten, Rainer Hirsch-Luipold, Stephan Joubert, Craig R. Koester, Bart J. Koet, Michael Labahn, Tobias Nicklas, Bert Jan Lietaert Peerbolte, Udo Schnelle, Michael Theobald, D. Francois Tolmie, Joseph Verheyden, Ben Witherington, III, Ellen van Wolde, Michael Wolter, Mirjam Zimmermann, Ruben Zimmermann. (shrink)

Using survey data collected from chief executives of nonprofit organizations and financial performance information, the current study examined the influence of the individual chief executive characteristics on their perception of organization performance. The study found that executives with internal Locus of Control, high collectivism values, and analytical decision styles have greater convergence between their perceptions of performance and a financial measure. The study findings also offer support for existing theories that suggest executive cognitions play a significant role in filtering information, (...) ultimately influencing the accuracy of perceptions and the effectiveness of strategic choices. (shrink)

The idea of sociability - a person’s disposition and ability to communicate and live in the community - goes through the whole history of philosophy. Due to the peculiarity of translations, this term and the whole tradition related to it have been lost to the Russian reader. The article discusses some tendencies in comprehending the idea of sociability in early modern moral philosophy. The key to this consideration is F. Hutcheson’s essay On the Natural Sociability of Mankind, the title of (...) which contains the very term “sociability” and which presents the main essential points in a discussion of the issue in the first third of the 18 th century. One can distinguish two main approaches to the problem. According to one of them, sociability determined by various human natural needs is the basis of social relations, and a person becomes a moral agent as a social being (H. Grotius, T. Hobbes, S. Pufen-dorf, B. Mandeville). According to another approach, sociability is a manifestation of a person’s natural tendency to care for the good of others, and its consistent implementation leads to the formation of community and supports its stability (Cambridge Platonists, Shaftesbury, Hutcheson, J. Butler, D. Hume, A. Smith). Representatives of both approaches recognized contradiction in manifestations of sociability or in its nature. I. Kant theoretically overcame the confrontation between these approaches and conceptualized the contradiction and associated it with the human nature. According to Kant, the “unsociable sociability” is given in the fact that a person has a tendency to sociability but also a tendency to self-assertion at the expense of others. However, despite the presence of asocial features (evil principle), Kant considered the person’s inherent sociability (good principle) as a prerequisite for culture and as one of the most important conditions of possibility of morality. (shrink)

RESUMEN A partir del examen de la noción de dialéctica ofrecida por Jean-Paul Sartre en “Cuestiones de método”, se identifican tres características propias de dicha noción presentes en la dialéctica de Hegel: el papel de la reflexión, la negatividad y la relación entre la dialéctica y la subjetividad. ABSTRACT On the basis of the analysis of the notion of dialectics set forth by Jean-Paul Sartre in “Search for a Method”, the article identifies three characteristics of said notion that were already (...) present in Hegel’s dialectics: the role of reflection, negativity, and the relation between dialectics and subjectivity. (shrink)

This book introduces readers to the topic of explanation. The insights of Plato, Aristotle, J.S. Mill and Carl Hempel are examined, and are used to argue against the view that explanation is merely a problem for the philosophy of science. Having established its importance for understanding knowledge in general, the book concludes with a bold and original explanation of explanation.

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 20 (2000) 311-315 [Access article in PDF] Book Review Fire and Water: Basic Issues in Asian Buddhism and Christianity Fire and Water: Basic Issues in Asian Buddhism and Christianity. By Aloysius Pieris, S. J. Maryknoll: Orbis Books, 1996. Aloysius Pieris, Jesuit priest and Buddhist scholar, is well known in theological and interreligious dialogue circles in Asia, and this is the third collection of essays of his to (...) be published in the Faith Meets Faith Series of Orbis Books. The eighteen essays which make up this book, all previously published elsewhere, are conveniently put together in three sections, under the following headings: 1) Women and Religion: Buddhist and Christian Appropriation of Feminist Criticism; 2) issues in Theology, Religion and Society; and 3) questions of Spirituality and Human Liberation. To merely summarize the content of the essays and offer a third-party critique would do injustice to the book, and could even mislead one who peruses such a summary into thinking one thereby "knows" what the book or Pieris is about. Such a hasty conclusion would deprive a would-be reader of the powerful experience that awaits in wrestling with Pieris through each essay of this volume. Judith Berling puts it well in her blurb at the back, pointing out that the author "uses poetry, evocative symbolism, and humor to offer a theological call to action in a voice that is liberationist, Asian, and feminist." Indeed, this volume invites one to a way of seeing that can also transform one's way of being in this world marked by increasing violence, poverty, and a systemic kind of oppression dehumanizing to both the perpetrators as well as the victims.The title of the present volume, Fire and Water, alludes to a dynamic dipolarity, masterfully sketched for the reader by Paul Knitter in his foreword, which underlies the author's vision of reality and vivifies much of his writing. The masculine and the feminine, the (Buddhist) gnostic and the (Christian) agapeic, the metacosmic (transcendent) [End Page 311] and the cosmic (immanent), the prophetic and the mystical, are different ways of naming this dipolarity. The way to ultimate liberation is in the effective embrace of both poles in complementarity and mutual interplay, whereas taking one pole in preference over the other results in a warped vision or mode of being, in imbalance, or even in abuse.In this review I would like to simply echo some key themes that will jump at one perusing the essays, reiterating that the very act of reading them can of itself be a transformative experience for an open-minded, open-hearted, and open-handed reader.The thrust of the six essays comprising the first section can perhaps be summed up in the thesis as formulated by the author himself: "Religion cannot survive in the future without appropriating the feminist critique, just as feminism cannot achieve its liberative goal without the aid of a religion so critiqued" (p. 62). Behind this statement is Pieris' emphatically critical stance, on the one hand, against all forms of patriarchal religion, whether Christian, Buddhist, Hindu, or other, which has justified, lent a hand in, or continued to perpetrate the physical, psychological, and especially religious abuse of women, and on the other hand, against secularist (or anti-religious) kinds of feminist theory that take off on what he enumerates as "five false starts" (pp. 50-51), which only result in unnecessary dichotomies that truncate the understanding of the goal of liberation, and consequently of the human as such.Pieris offers a vision of liberation centered on what he terms the humanum. This refers to the point of ultimate perfection to which the human, that is, "whatever pertains to men and women as self-conscious, other-oriented, and dreaming components of the cosmos," has the capacity to carry the cosmos. In this context, the human is no other than "this self-transcendent capacity immanent in the cosmos, this power to unfold within itself the Other, which is ever present from the first moment of evolution." To be human is inherently to be endowed... (shrink)

The aim of this series is to bring together important recent writings in major areas of philosophical inquiry, selected from a variety of sources, mostly periodicals, which may not be conveniently available to the university student or the general reader. The editor of each volume contributes an introductory essay on the items chosen and on the questions with which they deal. A selective bibliography is appended as a guide to further reading. This volume presents a selection of the most important (...) recent writings on the nature of explanation. It covers a broad range of topics from the philosophy of science to the central philosophical terrain of the theory of knowledge. The distinguished contributors include Peter Achinstein, Wesley C. Salmon, Carl G. Hempel, Philip Kitcher, Bas C. van Fraassen, Jaegwon Kim, B. Brody, Timothy McCarthy, Peter Railton, David Lewis, Peter Lipton, James Woodward, and Robert J. Matthews. (shrink)

This article analyzes the meaning and philosophical scope of «Funes el memorioso», a short story by J.L.Borges. «Funes el memorioso» participates in the productive symbiosis between literature and philosophy, a characteristic which is evident in most of Borges’ work and which has taken Borge’s creations to the summit of Western culture. Furthermore, by reading «Funes el memorioso» we can draw connections between the work of J.L.Borges and some of the most important authors in the History of Philosophy. We try to (...) show that the epistemologies of Plato and Hume, authors that Borges knew perfectly, influenced the creation of this short story in a decisive manner. (shrink)

In his note [5] Hausner states a simple combinatorial principle, namely: $$(H)\left\{ {\begin{array}{*{20}c} {if f is a function a non - empty finite set \sigma into itself, p a} \\ {prime, f^p = i_\sigma and \sigma _0 the set of fixed points of f, then } \\ {\left| \sigma \right| \equiv \left| {\sigma _0 } \right|(mod p).} \\\end{array}} \right.$$ .He then shows how this principle can be used to prove:Fermat's little theorem,Cauchy's theorem for finite groups,Lucas' theorem for binomial numbers.Letε=(0,1, ...),ℱ (...) 1−1 the family of all one-to-one functions from a subset ofε intoε andℳ 1−1 the family of all p.r. (i.e., partial recursive) one-to-one functions from a subset ofε intoε. A subsetα of ε is finite, ifα is not equivalent to a proper subset under a function inℱ 1−1. The setα is calledisolated, if it is not equivalent to a proper subset under a function inℳ 1−1. An isolated set can also be defined as a subset ofε which has no infinite r.e. (i.e., recursively enumerable) subset. While every finite set is isolated, there are $c = 2^{\aleph _0 }$ infinite sets which are isolated; these sets are calledimmune. It is the purpose of this paper to generalize (H) to a principle (H*) for isolated sets and to show how (H*) can be used to prove generalizations of Fermat's little theorem and Cauchy's theorem for finite groups. We have been unable to generalize Lucas' theorem in a similar manner. (shrink)

The inverse of the distance between two structures $\mathscr{A} \not\equiv \mathscr{B}$ of finite type $\tau$ is naturally measured by the smallest integer $q$ such that a sentence of quantifier rank $q - 1$ is satisfied by $\mathscr{A}$ but not by $\mathscr{B}$. In this way the space $\operatorname{Str}^\tau$ of structures of type $\tau$ is equipped with a pseudometric. The induced topology coincides with the elementary topology of $\operatorname{Str}^\tau$. Using the rudiments of the theory of uniform spaces, in this elementary note we (...) prove the convergence of every Cauchy net of structures, for any type $\tau$. (shrink)

The inverse of the distance between two structures $\mathscr{A} \not\equiv \mathscr{B}$ of finite type τ is naturally measured by the smallest integer q such that a sentence of quantifier rank q - 1 is satisfied by A but not by B. In this way the space $\operatorname{Str}^\tau$ of structures of type τ is equipped with a pseudometric. The induced topology coincides with the elementary topology of $\operatorname{Str}^\tau$ . Using the rudiments of the theory of uniform spaces, in this elementary note (...) we prove the convergence of every Cauchy net of structures, for any type τ. (shrink)

En los últimos años de su vida, el poeta nicaragüense Rubén Darío volvió a trabajar el cuento fantástico porque el género ofrecía la mejor expresión narrativa a la confusión y la incredulidad que estaba viviendo. En septiembre de 1910 Darío hizo su única visita a México, que estaba entonces en vísperas de la gran Revolución que derrocaría a la dictadura de Porfirio Díaz, la cual había controlado al país por treinta y cuatro años. La experiencia de estar en medio de (...) una gran agitación social, como un invitado de honor y, sin embargo, no habérsele permitido ascender a la capital, fue probablemente una inspiración para su penúltimo cuento, “Huitzilopoxtli: leyenda mexicana” (1977a). (shrink)

Cosmological boundary conditions for particles and fields are often discussed as a Cauchy problem, in which configurations and conjugate momenta are specified on an “initial” time slice. But this is not the only way to specify boundary conditions, and indeed in action-principle formulations we often specify configurations at two times and consider trajectories joining them. Here, we consider a classical system of particles interacting with short range two body interactions, with boundary conditions on the particles’ positions for an initial and (...) a final time. For a large number of particles that are randomly arranged into a dilute gas, we find that a typical system trajectory will spontaneously collapse into a small region of space, close to the maximum density that is obtainable, before expanding out again. If generalizeable, this has important implications for the cosmological arrow of time, potentially allowing a scenario in which both boundary conditions are generic and also a low-entropy state “initial” state of the universe naturally occurs. (shrink)

Gleason-type theorems derive the density operator and the Born rule formalism of quantum theory from the measurement postulate, by considering additive functions which assign probabilities to measurement outcomes. Additivity is also the defining property of solutions to Cauchy’s functional equation. This observation suggests an alternative proof of the strongest known Gleason-type theorem, based on techniques used to solve functional equations.

The foundations of analysis offered by Cauchy and Riemann were not immediately welcomed by the mathematical community. Before 1870 the foundations of mathematics were considered more or less a national affair. In this paper, Dutch ideas of rigour in analysis between 1840 and 1870 will be discussed. These ideas show that Dutch mathematicians were aware of developments abroad but preferred the concept of infinitesimals as a foundation of mathematics.

The authors would like to make the corrections to the original article described below.

One of the most influential scientific treatises in Cauchy's era was J.-L. Lagrange's Mécanique Analytique, the second edition of which came out in 1811, when Cauchy was barely out of his teens. Lagrange opens his treatise with an unequivocal endorsement of infinitesimals. Referring to the system of infinitesimal calculus, Lagrange writes:Lorsqu'on a bien conçu l'esprit de ce système, et qu'on s'est convaincu de l'exactitude de ses résultats par la méthode géométrique des premières et dernières raisons, ou par la méthode analytique (...) des fonctions dérivées, on peut employer les infiniment petits comme un instrument sûr et commode pour abréger et simplifier les demonstrations.Lagrange's renewed enthusiasm for .. (shrink)